Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates
نویسندگان
چکیده
منابع مشابه
Novel Agents against Miltefosine-Unresponsive Leishmania donovani.
Visceral leishmaniasis is a deadly endemic disease. Unresponsiveness to the only available oral drug miltefosine poses a big challenge for the chemotherapy of the disease. We report a novel molecule, PS-203 {4-(4,4,8-trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester}, as effective against a miltefosine-unresponsive strain of the parasite. Further, combinations of PS-203 wit...
متن کاملTransmission potential of antimony-resistant leishmania field isolates.
We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight...
متن کاملRole of aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani.
Antimonial-containing drugs are the first line of treatment against Leishmaniasis. Resistance to antimonials in Leishmania is proposed to be due to reduced uptake of trivalent antimony (SbIII) through the aquaglyceroporin (AQP1). We investigated the uptake of SbIII and involvement of aquaglyceroporin in developing antimony resistance phenotype in Leishmania donovani clinical isolates. SbIII acc...
متن کاملRole of Efflux Pumps and Intracellular Thiols in Natural Antimony Resistant Isolates of Leishmania donovani
BACKGROUND In view of the recent upsurge in the phenomenon of therapeutic failure, drug resistance in Leishmania, developed under natural field conditions, has become a great concern yet little understood. Accordingly, the study of determinants of antimony resistance is urgently warranted. Efflux transporters have been reported in Leishmania but their role in clinical resistance is still unknow...
متن کاملAntimony-resistant clinical isolates of Leishmania donovani are susceptible to paromomycin and sitamaquine.
Widespread antimonial resistance in anthroponotic visceral leishmaniasis (VL) makes it critical to monitor the susceptibility of prevailing field isolates to upcoming antileishmanials in order to frame the right treatment policies to protect these drugs against development of resistance. We aimed to generate the baseline data on natural in vitro susceptibility to paromomycin and sitamaquine in ...
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ژورنال
عنوان ژورنال: Molecular and Biochemical Parasitology
سال: 2010
ISSN: 0166-6851
DOI: 10.1016/j.molbiopara.2010.05.015